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M9480504.TXT
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1994-08-20
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Document 0504
DOCN M9480504
TI Nuclear localization of foamy virus Gag precursor protein.
DT 9410
AU Schliephake AW; Rethwilm A; Institut fur Virologie und Immunbiologie,
Wurzburg, Germany.
SO J Virol. 1994 Aug;68(8):4946-54. Unique Identifier : AIDSLINE
MED/94309158
AB All foamy viruses give rise to a strong nuclear staining when infected
cells are reacted with sera from infected hosts. This nuclear
fluorescence distinguishes foamy viruses from all other retroviruses.
The experiments reported here indicate that the foamy virus Gag
precursor protein is transiently located in the nuclei of infected cells
and this is the likely reason for the typical foamy virus nuclear
fluorescence. By using the vaccinia virus expression system, a conserved
basic sequence motif in the nucleocapsid domain of foamy virus Gag
proteins was identified to be responsible for the nuclear transport of
the gag precursor molecule. This motif was also found to be able to
direct a heterologous protein, the Gag protein of human immunodeficiency
virus, into the nucleus.
DE Amino Acid Sequence Animal Biological Transport Cell Line Cell
Nucleus/METABOLISM Cercopithecus aethiops Fluorescent Antibody
Technique Gene Products, gag/*METABOLISM Hamsters Human Mice
Molecular Sequence Data Protein Precursors/*METABOLISM Sequence
Homology, Amino Acid Spumavirus/*GENETICS/PHYSIOLOGY Support, Non-U.S.
Gov't Tumor Cells, Cultured Vero Cells Virus Replication JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).